МАКРО-АСПАРТАТАМИНОТРАНСФЕРАЗА
Аннотация
Измерение активности ферментов сыворотки крови – один из наиболее распространенных лабораторных тестов. Причиной повышенной активности могут быть ненормальные с высокой молекулярной массой ферменты, так называемые макроэнзимы. Макроэнзимы могут выявляться у здоровых лиц, но также могут быть и у лиц с наличием заболеваний. Макро-аспартатаминотрансфераза (макро-АсАТ) является макроэнзимом, продуцируется путем формирования комплекса АсАТ с иммуноглобулинами сыворотки (IgA, IgG или обоими). Персистирование макро-АсАТ – редкое доброкачественное состояние. Макро-АсАТ, как правило, характеризуется повышенной активностью сывороточной AсАТ. Статья содержит анализ литературных данных о пациентах с макро-АсАТ.Литература
Ono S, Kurata C, Nishimura N, Kawashima H, Yoneima R, Tai Y, Tatsumi E, Miyamoto M, Yada N, Yoshimoto K, Nishio K. Importance of Laboratory Detection of MacroAspartate Aminotransferase. Int J Gen Med. 2019;12:433-436. https://doi.org/10.2147/IJGM.S224281.
Rohani P, Imanzadeh F, Sayyari A, Kazemi Aghdam M, Shiari R. Persistent elevation of aspartate aminotransferase in a child after incomplete Kawasaki disease: a case report and literature review. BMC Pediatr. 2020;20(1):73. https://doi.org/10.1186/s12887-020-1975-8.
Shen H, Damcott C, Shuldiner SR, Chai S, Yang R, Hu H, Gibson Q, Ryan KA, Mitchell BD, Gong DW. Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels. J Hum Genet. 2011;56(11):801-5. https://doi.org/10.1038/jhg.2011.105.
Bruguera M. Practical guidelines for examination of adults with asymptomatic hypertransaminasaemia. Gastroenterol Hepatol. 2017;40(2):99-106. https://doi.org/10.1016/j.gastrohep.2016.03.001. (Spanish, English).
Patt CH, Yoo HY, Dibadj K, Flynn J, Thuluvath PJ. Prevalence of transaminase abnormalities in asymptomatic, healthy subjects participating in an executive health-screening program. Dig Dis Sci. 2003;48(4):797-801. https://doi.org/10.1023/a:1022809430756.
Lee M, Vajro P, Keeffe EB. Isolated aspartate aminotransferase elevation: think macro-AST. Dig Dis Sci. 2011;56(2):311-3. https://doi.org/10.1007/s10620-011-1575-4.
Berk JE, Kizu H, Wilding P, Searcy RL. Macroamylasemia: a newly recognized cause for elevated serum amylase activity. N Engl J Med. 1967;277(18):941-6. https://doi.org/10.1056/NEJM196711022771801.
Levitt MD, Cooperband SR. Hyperamylasemia from the binding of serum amylase by an 11S IgA globulin. N Engl J Med. 1968;278(9):474-9. https://doi.org/10.1056/NEJM196802292780903.
Moriyama T, Tamura S, Nakano K, Otsuka K, Shigemura M, Honma N. Laboratory and clinical features of abnormal macroenzymes found in human sera. Biochim Biophys Acta. 2015;1854(6):658-67. https://doi.org/10.1016/j.bbapap.2014.10.015.
Remaley AT, Wilding P. Macroenzymes: biochemical characterization, clinical significance, and laboratory detection. Clin Chem. 1989;35(12):2261-70. https://doi.org/10.1093/clinchem/35.12.2261
Triester SL, Douglas DD. Development of macro-aspartate aminotransferase in a patient undergoing specific allergen injection immunotherapy. Am J Gastroenterol. 2005;100(1):243-5. https://doi.org/10.1111/j.1572-0241.2005.41284.x.
Werner T, Vargas HE, Chalasani N. Macro-aspartate aminotransferase and monoclonal gammopathy: a review of two cases. Dig Dis Sci. 2007;52(5):1197-8. https://doi.org/10.1007/s10620-006-9555-9.
Kulecka M, Wierzbicka A, Paziewska A, Mikula M, Habior A, Janczyk W, Dabrowska M, Karczmarski J, Lazniewski M, Ginalski K, Czlonkowska A, Socha P, Ostrowski J. A heterozygous mutation in GOT1 is associated with familial macro-aspartate aminotransferase. J Hepatol. 2017;67(5):1026-1030. https://doi.org/10.1016/j.jhep.2017.07.003.
Briani C, Zaninotto M, Forni M, Burra P. Macroenzymes: too often overlooked. J Hepatol. 2003;38(1):119. https://doi.org/10.1016/s0168-8278(02)00333-1.
Caropreso M, Fortunato G, Lenta S, Palmieri D, Esposito M, Vitale DF, Iorio R, Vajro P. Prevalence and long-term course of macro-aspartate aminotransferase in children. J Pediatr. 2009;154(5):744-8. https://doi.org/10.1016/j.jpeds.2008.11.010.
Patteet L, Simoens M, Piqueur M, Wauters A. Laboratory detection of macro-aspartate aminotransferase: case report and evaluation of the PEG-precipitation method. Clin Biochem. 2012;45(9):691-3. https://doi.org/10.1016/j.clinbiochem.2012.03.004.
Davidson DF, Watson DJ. Macroenzyme detection by polyethylene glycol precipitation. Ann Clin Biochem. 2003;40(Pt 5):514-20. https://doi.org/10.1258/000456303322326425.
Castiella A, Aguayo FJ, Rueda M, Fernandez J, Zapata E. Macroaspartate aminotransferase (Macro-AST) a rare cause of hipertransaminasemia: another way to diagnosis? J Clin Gastroenterol. 2006;40(7):655. https://doi.org/10.1097/00004836-200608000-00024.
Beşer OF, Laçinel S, Gülcü D, Kutlu T, Cullu Çokuğraş F, Erkan T. An easy method for diagnosing macro-aspartate aminotransferase: a case series. Turk J Gastroenterol. 2014;25(5):568-70. https://doi.org/10.5152/tjg.2014.7504.
Mrosewski I, Bredlau B, Öztürk Y, Switkowski R. Persistent Isolated Elevation of Aspartate Aminotransferase in an Asymptomatic Female Patient: a Case Report and Review of Current Literature. Clin Lab. 2019;65(8). https://doi.org/10.7754/Clin.Lab.2019.190205.
Chtioui H, Mauerhofer O, Günther B, Dufour JF. MacroAST in an asymptomatic young patient. Ann Hepatol. 2010;9(1):93-5.
Lord R, Fahie-Wilson M, Suri S. A paediatric case of macro aspartate aminotransferase. Ann Clin Biochem. 2008;45(Pt 3):323-4. https://doi.org/10.1258/acb.2007.007094.
Zhan MR, Liu X, Zhang MY, Niu JQ. Isolated elevated aspartate aminotransferase in an asymptomatic woman due to macro-aspartate aminotransferase: A case report. World J Clin Cases. 2019;7(24):4414-4419. https://doi.org/10.12998/wjcc.v7.i24.4414.
Jain S, Sonthalia N, Thanage R, Chandnani S, Rathi PM, Tiwari D, Rathi S. Familial Macro-Aspartate Transaminase - An Unsolved Puzzle? Indian J Pediatr. 2019;86(11):1060-1061. https://doi.org/10.1007/s12098-019-02951-2.
