РОЛЬ ИЗОФОРМ ЦИТОХРОМА Р450 ЭНДОПЛАЗМАТИЧЕСКОГО РЕТИКУЛУМА ГЕПАТОЦИТОВ В МЕТАБОЛИЗМЕ ЭТАНОЛА
Аннотация
Введение. Известно, что системное окисление этанола в печени включает три метаболических пути, которые могут функционировать параллельно: с участием алкогольдегидрогеназ, ферментов микросомального окисления и каталазы пероксисом. Цитохром Р450-зависимая микросомальная этанолокисляющая система играет незначительную роль в метаболизме небольших количеств этанола, но индуцируется при его избытке и приобретает существенное значение при злоупотреблении им. Основные компоненты данной системы – изоформы цитохрома Р450 (CYP) гладкой эндоплазматической сети. Цель исследования. Охарактеризовать роль ключевых изоформ цитохрома Р450 в окисление этанола. Материал и методы. Проведен анализ современных литературных данных об участии основных изоформ цитохрома Р450 в метаболизме этанола в печени. Результаты. Представлены данные о первостепенной роли в метаболизме этанола цитохрома CYP2E1, а также вкладе в окисление этанола изоформ CYP1А2, CYP2В1/2, CYP2C, CYP3А4, CYP4B1. Выводы. Этанол метаболизируется многими CYP эндоплазматического ретикулума гепатоцитов. Учитывая важную роль CYP в процессах биотрансформации в печени, изучение роли отдельных изоформ CYP в метаболизме этанола имеет значение для прогнозирования изменения фармакокинетики лекарственных средств и метаболизма эндогенных соединений под воздействием этанола.
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