БИОХИМИЧЕСКИЕ МЕХАНИЗМЫ СИНТЕЗА И СЕКРЕЦИИ ИНСУЛИНА

  • В. М. Шейбак (V. М. Sheibak) УО «Гродненский государственный медицинский университет», Гродно, Беларусь
Ключевые слова: инсулин, синтез, секреция, регуляция

Аннотация

Синтез инсулина β-клетками островков Лангерганса регулируется на уровне транскрипции, а также путем пост-трансляционной модификации и нутритивными факторами, влияющими на скорость трансляции белка. Секреция инсулина протекает в две фазы – быструю и медленную, которые во многом определяются энергетическим статусом β-клетки. Тесное взаимодействие между гормональным и нутритивным статусом организма обеспечивает функционирование эндокринного компонента поджелудочной железы как единого органа.

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Опубликован
2018-12-05