БИОХИМИЧЕСКИЕ МЕХАНИЗМЫ СИНТЕЗА И СЕКРЕЦИИ ИНСУЛИНА
Аннотация
Синтез инсулина β-клетками островков Лангерганса регулируется на уровне транскрипции, а также путем пост-трансляционной модификации и нутритивными факторами, влияющими на скорость трансляции белка. Секреция инсулина протекает в две фазы – быструю и медленную, которые во многом определяются энергетическим статусом β-клетки. Тесное взаимодействие между гормональным и нутритивным статусом организма обеспечивает функционирование эндокринного компонента поджелудочной железы как единого органа.
Литература
1. Shejbak, V. M. Sintez i sekrecija insulina: rol' kationov cinka [Synthesis and secretion of insulin: role of zinc cations] / V. M. Shejbak // Zhurnal Grodnenskogo gosudarstvennogo medicinskogo universiteta [Journal of the Grodno State Medical University]. – 2015. – № 1. – S. 5-8. (Russian)
2. Adaptations of leptin, ghrelin or insulin during weight loss as predictors of weight regain: a review of current literature / K. Strohacker [et al.] // Int. J. Obes. – 2014. – Vol. 38, № 3. – P. 388-396.
3. Amino acid metabolism, insulin secretion and diabetes / P. Newsholme [et al.] // Biochem. Soc. Trans. – 2007. – Vol. 35, № 5. – P. 1180-1186.
4. A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli / R. Roduit [et al.] // Diabetes. – 2004. – Vol. 53, № 4. – P. 1007-1019.
5. A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first – phase insulin secretion in mouse β cells / S. Barg [et al.] // Diabetes. – 2002. – Vol. 51, suppl. 1. – P. 74-82.
6. Baumgard, L. H. Insulin: pancreatic secretion and adipocyte regulation / L. H. Baumgard, G. J. Hausman, M. V. Sanz Fernandez // Domest. Anim. Endocrinol. – 2016. – Vol. 54. – P. 76-84.
7. Braun, M. The somatostatin receptor in human pancreatic β-cells / M. Braun // Vitam. Horm. – 2014. – Vol. 95. – P. 165-193.
8. Combined treatment of somatostatin analogues with pegvisomant in acromegaly / S. E. Franck [et al.] // Endocrine. – 2016. – Vol. 52, № 2. – P. 206-213.
9. De Meyts, P. Insulin and its receptor: structure, function and evolution / P. De Meyts // Bioessays. – 2004. – Vol. 26, № 12. – 1351-1362.
10. Donor islet endothelial cells in pancreatic islet revascularization / D. Nyqvist [et al.] // Diabetes. – 2011. – Vol. 60, № 10. – P. 2571-2577.
11. Doyle, M. E. Mechanisms of action of glucagon-like peptide 1 in the pancreas / M. E. Doyle, J. M. Egan // Pharmacol. Ther. – 2007. – Vol. 113, № 3. – P. 546-593.
12. Drazin, B. Molecular mechanisms of insulin resistance / B. Drazin // Diabetes. – 2006. – Vol. 55, № 7. – P. 2392-2397.
13. Estrogen signaling prevents diet-induced hepatic insulin resistance in male mice with obesity / L. Zhu [et al.] // Am. J. Physiol. Endocrinol. Metab. – 2014. – Vol. 306, № 10. – P. 1188- 1197.
14. Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors / M. Volante [et al.] // Clin. Endocrinol. Metab. – 2002. – Vol. 87. – P. 1300-1308.
15. Fu, Z. Regulation of Insulin Synthesis and Secretion and Pancreatic Beta – Cell Dysfunction in Diabetes / Z. Fu, E. R. Gilbert, D. Liu // Curr. Diabetes. Rev. – 2013. – Vol. 9, № 1. – P. 25-53.
16. Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet / R. K. Benninger [et al.] // J. Physiol. – 2011. – Vol. 589. – P. 5453-5466.
17. Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential / J. Gromada [et al.] // Basic Clin. Pharmacol. Toxicol. – 2004. – Vol. 95, № 6. – P. 252-262.
18. Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell / J. T. Low [et al.] // Diabetologia. – 2013. – Vol. 56, № 12. – P. 2629-2637.
19. Gupte, A. A. Estrogen: An emerging regulator of insulin action and mitochondrial function / A. A. Gupte, H. J. Pownall, D. J. Hamilton // J. Diabetes Res. – 2015. – Vol. 2015. – P. 1-9.
20. Huang, X. F. Intracellular transport of proinsulin in pancreatic beta-cells. Structural maturation probed by disulfide accessibility / X. F. Huang, P. Arvan // J. Biol. Chem. – 1995. – Vol. 270, № 35. – P. 20417-20423.
21. Hay, C. W. Comparative analysis of insulin gene promoters: implications for diabetes research / C. W. Hay, K. Docherty // Diabetes. – 2006. – Vol. 55, № 12. – P. 3201-3213.
22. Incretins: their physiology and application in the treatment of diabetes mellitus / H. M. Tasyurek [et al.] // Diabetes. Metab. Res. Rev. – 2014. – Vol. 30, № 5. – P. 354-371.
23. In vivo and in vitro glucose-induced biphasic insulin secretion in the mouse: pattern and role of cytoplasmic Ca2+ and amplification signals in beta-cells / J. C. Henquin [et al] // Diabetes. – 2006. – Vol. 55, № 2. – P. 441-451.
24. Kim, W. The role of incretins in glucose homeostasis and diabetes treatment / W. Kim, J. M. Egan // Pharmacol. Rev. – 2008. – Vol. 60. – P. 470-512.
25. Long-term melatonin administration reduces hyperinsulinemia and improves the altered fatty acid compositions in type 2 diabetic rats via the restoration of delta-5 desaturase activity / S. Nishida [et al.] // J. Pineal. Res. – 2002. – Vol. 32, № 1. – P. 26-33.
26. Maechler, P. Mitochondrial glutamate acts as a messenger in glucose – induced insulin exocytosis / P. Maechler, C. B. Wollheim // Nature. – 1999. – Vol. 402, № 6762. – P. 685- 689.
27. Maechler, P. Mitochondrial function and insulin secretion / P. Maechler // Mol. Cell. Endocrinol. – 2013. – Vol. 379, № 1-2. – P. 12-18.
28. Melatonin inhibits insulin secretion and decreases PKA levels without interfering with glucose metabolism in rat pancreatic islets / M. C. Picinato [et al.] // J. Pineal. Res. – 2002. – Vol. 33, № 3. – P. 156-160.
29. On high-frequency insulin oscillations / O. Schmitz [et al] // Ageing Res. Rev. – 2008. – Vol. 7, № 4. – P. 301-305.
30. Perry, R. J. Pleotropic effects of leptin to reverse insulin resistance and diabetic ketoacidosis / R. J. Perry, K. F. Petersen, G. I. Shulman // Diabetologia. – 2016. – Vol. 59, № 5. – P. 933- 937.
31. Peschke, E. Melatonin and рancreatic islets: interrelationships between melatonin, insulin and glucagon / E. Peschke, I. Bähr, E. Mühlbauer // Int. J. Mol. Sci. – 2013. – Vol. 14, № 4. – P. 6981-7015.
32. Physiological mechanisms of action of incretin and insulin in regulating skeletal muscle metabolism / H. Abdulla [et al.] // Curr. Diabetes Rev. – 2014. – Vol. 10, № 5. – P. 327-335.
33. Ramasarma, T. A glucose - centric perspective of hyperglycemia / T. Ramasarma, M. Rafi // Indian J. Exp. Biol. – 2016. – Vol. 54, № 2. – P. 83-99.
34. Ravnskjaer, K. Role of the cAMP pathway in glucose and lipid metabolism / K. Ravnskjaer, A. Madiraju, M. Montminy // Handb. Exp. Pharmacol. – 2016. – Vol. 233. – P. 29-49.
35. Rose, D. P. Biochemical and molecular mechanisms for the association between obesity, chronic inflammation, and breast cancer / D. P. Rose, L. Vona-Davis // Biofactors. – 2014. – Vol. 40, № 1. – P. 1-12.
36. Rorsman, P. Insulin granule dynamics in pancreatic β cells / P. Rorsman, E. Renström // Diabetologia. – 2003. – Vol. 46, № 8. – P. 1029-1045.
37. Sears, B. The role of fatty acids in insulin resistance / B. Sears, M. Perry // Lipids Health Dis. – 2015. – Vol. 14. – P. 121.
38. The importance of redox shuttles to pancreatic beta-cell energy metabolism and function / K. Bender [et al.] // Biochem. Soc. Trans. – 2006. – Vol. 34, № 5. – P. 811-814.
39. The integrative role of leptin, oestrogen and the insulin family in obesity – associated breast cancer: potential effects of exercise / S. Schmidt [et al.] // Obes. Rev. – 2015. – Vol. 16, № 6. – P. 473-487.
40. The role of melatonin in diabetes: therapeutic implications / S. Sharma [et al.] // Arch. Endocrinol. Metab. – 2015. – Vol. 59, № 5. – P. 391-399.
41. The structure of 2 Zn pig insulin crystals at 1.5. A resolution / E. N. Baker [et al.] // Philos. Trans. R. Soc. Lond. B. Biol. Sci. – 1988. – Vol. 319, № 1195. – P. 369-456.
42. Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion / T. K. Bratanova-Tochkova [et al.] // Diabetes. – 2002. – Vol. 51. – P. 83-90.
43. Wang, Z. Mechanisms of biphasic insulin – granule exocytosis-roles of the cytoskeleton, small GTPases and SNARE proteins / Z. Wang, D. C. Thurmond // J. Cell. Sci. – 2009. – Vol. 122. – P. 893-903.
44. Weir, G. C. Islets of Langerhans: the puzzle of intraislet interactions and their relevance to diabetes / G. C. Weir, S. J. Bonner-Weir // J. Clin. Invest. – 1990. – Vol. 85, № 4. – P. 983-987.
