IODINE-CONTAINING THYROID HORMONES LIMIT THE DAMAGE OF THE GASTRIC MUCOSA UNDER STRESS
Abstract
Вackground. Currently, there has been an increase in the prevalence of diseases of the digestive system, so the search for new methods of prevention and treatment of gastrointestinal tract pathology is an urgent task of physiology and medicine.Objective. To study the gastroprotective effect of iodine-containing thyroid hormones (ITH) in stress and to reveal its mechanisms.
Materials and methods. The study was performed on male rats using stressors of various nature (emotional, physical, chemical) and duration (from 30 minutes to 3 months). Thyroid status was altered by administration of Mercazolil (25 mg / kg) or small doses of L-thyroxine (1.5-3.0 μg / kg). Gastric mucosa lesion was assessed on the basis of its severity, frequency, multiplicity, ulcer index or damage index.
Results. Various stressors cause damage to the gastric mucosa, its severity depending on the intensity and duration of the action. Experimental hypothyroidism induces more marked damage to the gastric mucosa under stress, whereas small doses of L-thyroxine have a gastroprotective effect under the same conditions. The main mechanisms of the protective action of ITH under stress are: limiting the intensification of lipid peroxidation and proteolysis, stimulating early genes expression.
Conclusion. The obtained results represent a new way to increase gastric mucosa resistance to the effects of stressors of different nature and intensity and can be applied in gastroenterology practice to justify the need for studying and correcting the thyroid status in a corresponding category of patients.
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