THE ROLE OF ERADICATION THERAPY IN CLINICAL COURSE OF HELICOBACTER-ASSOCIATED ROSACEA
Abstract
Background. There have been found some associations between rosacea and chronic inflammatory diseases of the stomach and intestines related to an increased colonization of the gastrointestinal tract with Helicobacter pylori.Objective. The aim of the study was to increase the effectiveness of rosacea treatment using differential therapy considering infection with Helicobacter pylori.
Materials and methods. We examined 128 patients with papulo-pustular rosacea. Depending on the therapy all patients were divided into 2 groups: group 1 (n=64) – was given eradication treatment, group 2 (n=64) – metronidazole.
Results. The article presents the results of clinical effectiveness of eradication therapy in patients with rosacea associated with Helicobacter pylori infection as compared to conventional therapy. The application of the suggested method of treatment increases the effectiveness and reduces the frequency of relapses (7.2% vs. 43.9%, p<0.001) as compared to conventional methods.
Conclusion. Among 128 examined patients, gastrointestinal diseases were detected in 91% of cases. It is recommended to include eradication therapy in the treatment regimen for patients with Helicobacter pylori-associated papulo-pustular rosacea.
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