INTERFERON-FREE THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C IN REAL CLINICAL PRACTICE
Abstract
Background. Antiviral 3D therapy for chronic hepatitis C has several advantages over treatment regimens, including pegylated interferons: a high degree of eradication of the virus, less pronounced side effects and a low risk of developing resistance.
Objective. To evaluate the effectiveness and safety of antiviral 3D therapy in patients with chronic hepatitis C, genotype 1 infection.
Materiasl and methods. The study involved 50 patients with chronic hepatitis C, genotype 1 infection. The mean age was 50.58±8.7 years. The average viral load of patients before the onset of 3D therapy was 4.45*10*5 ± 2.2 IU/mL. All patients were prescribed non-interferon triple therapy with paritoprevir, ombitasvir, dasabuvir for 12 weeks.
Results. Monitoring of the virological effectiveness of 3D therapy 30 days after the beginning of treatment revealed the cessation of viral replication in 90% of patients. After 60 days, all patients had a virologic response. At the end of therapy, after 90 days, the absence of viral load was detected in 96% of patients. At 12 and 24 weeks after completion of treatment, 96% of patients had a sustained virologic response. Side effects were moderately expressed and had a short-term character.
Conclusion. As a result of antiviral 3D therapy in patients with chronic hepatitis C, a stable virologic response was obtained in 96% of cases.
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