MORPHOLOGICAL CHARACTERISTICS OF CHRONIC GASTRITIS IN CHILDREN WITH CONNECTIVE TISSUE DYSPLASIA
Abstract
Background. Connective Tissue Dysplasia (CTD) affects the pathogenesis and clinical course of many diseases, including those of the digestive system.
Objective – to determine the nature and severity of morph-functional changes in stomach mucous membrane in children with chronic gastritis associated with different CTD severity.
Material and methods. 194 school-age children with chronic gastritis were examined (101 patients with mild CTD, 57 with severe and 36 patients without any connective tissue developmental disorders). Esophagogastroduodenoscopy with a targeted biopsy of the stomach, followed by detailed histological, morphometric and statistical analysis was performed for all patients. The presence and severity of CTD were verified according to the criteria of T. Milkovska-Dimitrova.
Results. In patients with chronic CTD-related gastritis destructive changes in the stomach were more common. As the severity of dysplasia increases, there has been noted a decrease of the epithelial layer height up to its flattening and desquamation. We have revealed a decrease of the protective properties of mucosa in the presence of aggressive factors of gastric juice, that contributes to the destructive lesions development.
Conclusion. The incidence of destructive processes in the gastric mucosa increases alongside with the rise of the severity of the connective tissue dysplastic changes.
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