https://www.enterair.pl/slot-gacor/

ПЕРСПЕКТИВЫ ИСПОЛЬЗОВАНИЯ БАКТЕРИАЛЬНЫХ ЛИПОПОЛИСАХАРИДОВ В ГЕПАТОЛОГИИ

  • С. А. Черняк УО "Гродненский государственный медицинский университет", Гродно, Беларусь http://orcid.org/0000-0001-6558-5044
Ключевые слова: бактериальные липополисахариды, иммуномодуляторы, гепатиты, фиброз печени

Аннотация

Введение. Исследование новых свойств бактериальных липополисахаридов (БЛПС), не связанных с их интоксикационной активностью, представляет большой интерес. Цель исследования – описание механизмов действия и оценка эффективности применения БЛПС. Материал и методы. Проведен анализ 32 литературных источников, опубликованных в период с 1962 по 2020 гг. Результаты. Установлено, что помимо иммуномодулирующего эффекта, БЛПС способны оказывать противовоспалительное, противоопухолевое, радиопротекторное действие, стимулировать регенерацию тканей. Широкий спектр терапевтической активности установлен при заболеваниях гепатобилиарной системы, что нашло подтверждение в ходе экспериментальных и клинических исследований. Назначение БЛПС приводит к укорочению манифестной стадии острых гепатитов, способствует быстрейшей норма- лизации функциональных печёночных проб и восстановлению морфологических изменений в печени. Заключение. Наличие у БЛПС гепатопротективных и антифиброзных свойств дает основания рекомендовать их врачам-гепатологам для более широкого применения в лечебной практике.

Литература

Brade H. Endotoxin in Health and Disease. New York;Basel: Marcel Dekker; 1999. 962 p.

Belova ZN, Budnitskaya PZ. Himicheskij sostav lipoidnoj chasti pirogenala R i znachenie lipoida A v pirogennoj aktivnosti preparata [Chemical composition of the lipoid part of pyrogenal P and the value of lipoid A in the pyrogenic activity of the drug]. Bjulleten jeksperimentalnoj biologii i mediciny [Bulletin of Experimental Biology and Medicine].1970;70(9):36-39. (Russian).

Lipopolisaharid [Lipopolysaccharide] [Internet]. Available from: https://clck.ru/9aZZS (Russian).

Fujihara M, Muroi M, Tanamoto K, Suzuki T, Azuma H, Ikeda H. Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex. Pharmacol Ther. 2003;100(2):171-194. https://doi.org/10.1016/j.pharmthera.2003.08.003.

Marshall JC. Lipopolysaccharide: an endotoxin or an exogenous hormone. Clin Infec Dis. 2005;41(7):470-480.

Ermoleva ZV, Vajsberg GE. Stimuljacija nespecificheskoj rezistentnosti organizma i bakterialnye polisaharidy. Moscow: Medicina; 1976. 182 p. (Russian).

Vasilyev VS. Lipopolisaharidy v processe immunogeneza: tendencii nauchnogo poiska i itogi izuchenija v uslovijah infekcionnoj patologii [Lipopolysaccharides during immunogenesis: scientific search trends and results in the study of infectious diseases]. Zhurnal Grodnenskogo gosudarstvennogo medicinskogo universiteta [Journal of the Grodno State Medical University]. 2014;1(45):98-103. (Russian).

Maslakov DA, Ejsmont KA, Maximovich NE. Sovremennye predstavlenija o biologicheskom dejstvii preparatov polisaharidnoj prirody [Current notions on polysaccharide nature, spreparations, biological effect]. Medicinskie Novosti [Medical news]. 2000;5(59):19-22. (Russian).

Kutina SN. Rol funkcionalnogo sostojanija sistemy mononuklearnyh fagocitov v razvitii CC1-4-cirroza i involjucii fibroznoj transformacii pecheni [masters thesis]. Irkutsk(Russia): Nauchnyj centr klinicheskoj i jeksperimentalnoj mediciny Sibirskogo otdelenija Rossijskoj Akademii medicinskih nauk; 2000. 29 p. (Russian).

Botchenko LV, Redechkina CI. Kliniko-immunologicheskie pokazateli jeffektivnosti prodigiozana pri virusnom gepatite u detej. In: Poljakov EM, ed. Virusy i virusnye zabolevanija. Sbornik statej. Kiev: Zdorovja; 1985. Iss. 13; p. 80-83 (Russian).

Prodigiozan: instrukcija po primeneniju, sostav i svojstva [Internet]. Available from: https://ru-transferfactor.ru/prodigiozan (Russian).

Budnickaja PZ. Vydelenie, himicheskaja harakteristika i nekotorye biologicheskie svojstva preparata pirogenala [masters thesis]. Moscow (Russia): NF Gamaleya Federal Research Center for Epidemiology & Microbiology; 1963. 14 p. (Russian).

Budnickaja PZ. K voprosu o himicheskoj prirode pirogennogo veshhestva pirogenala [On the chemical nature of thepyrogenic substance – pyrogenal]. Bjulleten jeksperimentalnoj biologii i mediciny [Bulletin of Experimental Biology and Medicine]. 1962;3(3):53-56. (Russian).

Avramenko MM. Vlijanie vysokomolekuljarnyh soedinenij tipa lipopolisaharidov na funkcionalnoe sostojanie pecheni na modeli CCl4-gepatoza u krys. In: Zlatkina AR, ed. Patologija pecheni i zhelchnyh putej. Trudy. Moscow: The State Budgetary Healthcare Institution of Moscow Area Moscows regional research clinical institute named after MF Vladimirskiy; 1971. p. 122-125. (Russian).

Avramenko MM, Gladyshev BN, Veinova MK, Afanaseva EM. Vlijanie pirogenala i gljukomannana na soderzhanie peptidov i nukleotid peptidov v tkani pecheni i belki syvorotki krovi pri CCl4-gepatoze u krys [Effect of pyrogenal and glucomannan on the content of liver peptides and nucleopeptides and of blood serum proteins under CCl4-hepatosis inrats]. Voprosy medicinskoj himii [Medical chemistry issues].1972;17(6):627-630. (Russian).

Vakulin GM. Morfologicheskie kriterii snizhenija pronicaemosti i trofiki cirroticheski izmenennoj pecheni krys i ih povyshenija pod vlijaniem pirogenala i piridoksalfosfata (morfometrija trasmissionnaja i rastrovaja jelektronnaja mikroskopija) [Morphological criteria of the loss of permeability and trophics of cirrhotically changed liver of rats and increase there of under the effect of pyrogenal and pyridoxalphospate (morphometry, transmission and scanningelectron microscop]. Bjulleten jeksperimentalnoj biologii i mediciny [Bulletin of Experimental Biology and Medicine]. 1993;116(12):645-650. (Russian).

Akopova VL. Funkcionalnoe sostojanie pecheni u bolnyh hronicheskim gepatitom i cirrozom pecheni v processe lechenija pirogenalom. In: Vasilenko VH, executive ed. Problemy diagnostiki i pojetapnogo lechenija gastrojenterologicheskih bolnyh. Materialy Vsesojuznogo plenumapravlenija obshhestva; 1974 Sept 6-8; Essentuki. Essentuki;1974. p. 147-148. (Russian).

Saveleva LA. Dinamika aktivnosti izofermentov malat- i laktat degidrogenazy pri lechenii pirogenalom cirroza pecheni u detej [Dynamics of the activity of isoenzymes of malic and lactic-dehydrogenases in pyrogenal treatment of cirrhosis of the liver in children]. Voprosy ohrany materinstva i detstva.1969;14(10):67-70. (Russian).

Saveleva LA, Drozdova GA. Fermentativnyj spektr syvorotki krovi pri lechenii pirogenalom cirroza pecheniu detej. In: Samson EI, executive ed. Voprosy profilaktiki, diagnostiki i lechenija zabolevanij organov pishhevarenija. Tezisy dokladov respublikanskoj nauchno-prakticheskoj konferencii vrachej-gastrojenterologov; 1970 Sept 9; Chernivtsi. Chernivtsi; 1970. p. 234-235. (Russian).

Petrova TR, Ponomareva EP. Vlijanie pirogenala na vnutrikletochnyj metabolizm i fagocitarnuju aktivnost lejkocitov u bolnyh hronicheskimi zabolevanijami pecheni [Effect of pyrogenal on intracellular metabolism and phagocytic activity of leukocytes in patients with chronic diseases of the liver]. Klinicheskaja medicina [Clinical medicine]. 1975;53(8):34-39. (Russian).

Zejgermaher GA. Rezultaty primenenija pirogenala v kompleksnom lechenii virusnogo gepatita (bolezni Botkina) [masters thesis]. Donetsk (Ukraine): Maxim Gorky Donetsk National Medical University; 1972. 20 p. (Russian).

Polomeev JuG. Kliniko-jepidemiologicheskaja harakteristika virusnogo gepatita A u voennosluzhashhih v uslovijah boevyh dejstvij [masters thesis]. Tomsk (Russia): Siberian State Medical University; 2004. 20 p. (Russian).

Gamaleya NB, Shostak OA, Makarova NYe, Uliyanova LI, Bisheva, Dmitriyeva IV. Pokazateli immuniteta u bolnyh alkogolizmom, oslozhnennym i ne oslozhnennym virusnymi gepatitami V i S, i vlijanie na nih immunomoduljatora pirogenala [Immunity indices in patients with alcoholism, complicated and not complicated with virus hepatitises B and C, and the immunomodulator effect]. Voprosy narkologii [Journal of Addiction Problems]. 2004;4:57-69. (Russian).

Surovikina MS, Saveleva LA, Tarasova LV, Domnikov AI, Surovikin VV. Pokazateli kininogeneza kak kriterij ocenki jeffektivnosti lechenija zabolevanij gepatobiliarnoj sistemy u detej. Almanah klinicheskoj mediciny [Almanac of Clinical Medicine]. 2002;5:236-243. (Russian).

Hochava AI. Nekotorye patogeneticheskie aspekty pirogenaloterapii pri virusnom gepatite. In: Getman II, executive ed. Voprosy jeksperimentalnoj i klinicheskoj gepatologii. Materialy respublikanskoj nauchnoj konferencii; 1976 Oct 21-22; Ternopil. Ternopil: Ternopil Medical Institute; 1976. p. 340-341. (Russian).

Boguckij MI. Vlijanie pirogenala na klinicheskoe techenie bolezni i funkcionalnoe sostojanie kory nadpochechnikov pri virusnom gepatite [masters thesis]. Kujbyshev (Russia): Samara State Medical University; 1978. 22 p. (Russian).

Vasilev VS. Kliniko-patogeneticheskoe obosnovanie primenenija pirogenala i prednizolona v kompleksnoj terapii virusnogo gepatita [masters thesis]. Leningrad (Russia): SM Kirov Military Medical Academy; 1980. 473 p. (Russian).

Tsyrkunov VM, Vasilyeva AN, Vasilyev VS, inventors; Grodno State Medical Institute, assignee. Sposob opredelenija individualnoj chuvstvitelnosti k pirogenaloterapii [Method for determining individual sensitivity to pyrogenal therapy]. RU patent 2009497. 1994 Mar 15. (Russian).

Tsyrkunov VM. Harakteristika processa degranuljacii bazofilnyh granulocitov krovi pri vvedenii pirogenala v jeksperimente. In: Krasilnikov AP, executive ed. Voprosy immunologii. Tezisy dokladov Pervoj respublikanskoj immunologicheskoj konferencii; 1982 Nov 25-26; Vitebsk. Vitebsk; 1982. p. 53-54. (Russian).

Chernyak SA. Kliniko-morfologicheskaja harakteristika i antifibroznaja terapija hronicheskogo gepatita C [Clinical and morphological characteristics and antifibrotic therapy of chronic hepatitis C] [masters thesis]. Grodno (Belarus): Grodno State Medical University, Belarusian State Medical University; 2020. 132 p. (Russian).

Pirogenal [Pyrogenal] [Internet]. Available from: https://www.rlsnet.ru/tn_index_id_4968.htm (Russian).

Shvarc JaSh. Reaktivnost makrofagalnoj sistemy pri fibroplasticheskih processah vospalitelnogo geneza: ocenka, mehanizmy reguljacii i patogeneticheskoe znachenie [masters thesis]. Novosibirsk (Russia): The Institute of Internal and Preventive Medicine Novosibirsk; 2010.

Опубликован
2021-01-13
Как цитировать
1.
Черняк СА. ПЕРСПЕКТИВЫ ИСПОЛЬЗОВАНИЯ БАКТЕРИАЛЬНЫХ ЛИПОПОЛИСАХАРИДОВ В ГЕПАТОЛОГИИ. journalHandG [Интернет]. 13 январь 2021 г. [цитируется по 29 март 2024 г.];4(2):160-4. доступно на: http://hepatogastro.grsmu.by/index.php/journalHandG/article/view/160
slot demo gratisslot gacor gampang menangSLOT DEMOslot pulsahttps://uptdlkk.kaltimprov.go.id/img/product/https://e-learning.iainponorogo.ac.id/thai/https://organisasi.palembang.go.id/userfiles/images/https://ditkapel.dephub.go.id/petikemas/tests/https://pmb.universitaspertamina.ac.id/popup/hari-ini/https://jdih.komnasham.go.id/img/banner/https://file.disdikbud.kaltimprov.go.id:8443/user/https://lms.binawan.ac.id/terbaik/slot gacor terbaikslot gacor maxwinslot gacor maxwinslot gacor hari inislot gacor terbaikslot gacor maxwinslot gacor 2024