THE ENERGY SUPPLY SYSTEM STATE OF THE GASTRIC MUCOSA CELLS IN CHILDREN WITH CHRONIC GASTRITIS AND CONNECTIVE TISSUE DYSPLASIA
Abstract
Background. Connective tissue dysplasia (CTD) has a modifying effect on the course of chronic gastritis (CG).
Objective. To assess the energy supply system state of the gastric fundic and pyloric mucosa cells in children with chronic gastritis associated with mild to severe CTD.
Material and methods. 34 school-age children with CG were examined. The patients underwent esophagogastroduodenoscopy with targeted biopsy of the gastric mucosa followed by histochemical examination.
The presence and severity of CTD were verified according to T. Milkowska-Dimitrova’s clinical criteria (1987).
Results. Inhibition of succinate dehydrogenase was observed in gastric fundic mucosa cells in children with CG regardless of the CTD severity, thus indicating the suppression of the most effective way of obtaining energy.
An increase in the activity of acid phosphatase was established, indicating the activation of lysosomes associated with increased autophagy, aimed at removing damaged membranes and organelles to cleanse the cytoplasm of cells. An increase in the activity of all cytoplasmic enzymes in question was observed in the pyloric region, demonstrating the activation of the processes of both aerobic and anaerobic methods of obtaining energy.
Conclusions. Significant disturbances were detected in the energy supply system of exocrinocytes of the gastric mucosa in children with CG, regardless of СTD severity.
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