MORPHOFUNCTIONAL FEATURES OF FEMALE REPRODUCTIVE ORGANS OF WHITE RATS OFFSPRING BORN TO FEMALES DEVELOPED IN CHOLESTASIS OF THEIR MOTHER

Abstract

Background. Mother’s cholestasis was found out to lead to reproductive system disorders in the offspring. It is not clear whether these disorders affect the second generation offspring that was born to them.
Objective. To establish structural features of the female reproductive system in the second generation offspring which was born to females developed in mother’s cholestasis.
Material and methods. Material - the reproductive organs of female nonbred white rats of the second generation aged 15-, 45- and 90-day-old. The methods of the study are histological, histochemical, morphometric and statistical.
Results. In the second generation offspring that was born to females developed during fetal and early postnatal period in cholestasis of their mother, delayed formation of follicles in the ovaries, structural disorders in their oocytes, follicular cells, in the membranes of the oviducts and the uterus have been revealed.
Conclusion. In the second generation offspring, obtained from females that developed in cholestasis of their mother, delayed development of the organs of the female reproductive system has been established.