PREDICTING OF TYPE 2 DIABETES MELLITUS DEVELOPMENT IN PATIENTS WITH CHRONIC HEPATITIS C
Abstract
Background. One of extrahepatic manifestations of chronic hepatitis C (CHC) is type 2 diabetes mellitus (DM), the timely diagnosis of which has important prognostic significance for both these pathologies.
Objective. To develop a method for predicting the development of type 2 diabetes in CHC.
Materials and methods. The subjects of the study were 65 patients with CHC of up to 15 years duration, without signs of liver cirrhosis. The C-peptide serum level of the patients was determined by the photometric method (the DRGC-Peptide EIA-1293 Kit, USA), the content of specific autoantibodies to insulin antigens (IAA) was assessed by ELISA (the DRG® IAA EIA-1593 Kit, USA).
Results. An increase in IAA level of more than 1.41 with a simultaneous increase in the serum C-peptide content greater than 2.21 ng/ml in patients with CHC makes it possible to predict the development of type 2 diabetes.
Conclusion. Monitoring of the C-peptide index and the level of specific IAA in patients with CHC allows predicting the development of type 2 diabetes in the early stages.
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