СТРУКТУРНАЯ ГЕТЕРОГЕННОСТЬ ЭНДОКРИННЫХ ОСТРОВКОВ ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ ЧАСТЬ II. РАЗЛИЧИЯ ОСТРОВКОВ ЛАНГЕРГАНСА В ЗАВИСИМОСТИ ОТ ОСОБЕННОСТЕЙ МОРФОГЕНЕЗА
Аннотация
В процессе развития у человека и других видов млекопитающих подробно рассмотрены взаимоотношения между протоковой системой, возникновением эндокринных клеток и формированием островков поджелудочной железы. Показано, что структурная и функциональная гетерогенность островков связана с особенностями их морфогенеза. Продемонстрированы различия локализации, микроархитектоники, кровоснабжения и иннервации островков в зависимости от времени и места их возникновения в дуктальной системе. Так, из проксимальной части протоковой системы поджелудочной железы островки развиваются раньше. Они располагаются в междольковых прослойках, образуют нейроинсулярные комплексы и обладают инсуло-венозным кровоснабжением, что более характерно для грызунов. Из дистальной части протоков развиваются островки с внутридольковой локализацией и инсуло-ацинарной портальной системой кровоснабжения, оказывающей влияние на окружающие ацинусы экзокринной паренхимы. Они преобладают у человека и крупного рогатого скота.
Литература
1. Mozhejko LA. Sravnitelnaja harakteristika vnutriostrovkovyh svjazej podzheludochnoj zhelezy cheloveka i zhivotnyh [Comparative characteristics of interinsular associations of human and animal pancreas]. Novosti mediko-biologicheskih nauk. 2015;1:94-98. (Russian).
2. Ruchelli ED. Pancreas. In: Ernst LM, Ruchelli ED, Huff DS, editors. Color Atlas of Fetal and Neonatal Histology. New York: Springer; 2011. p. 79-85.
3. Merkwitz C, Blaschuk OW, Schulz A, Lochhead P, Meister J, Ehrlich A, Ricken AM. The ductal origin of structur- al and functional heterogeneity between pancreatic islets. Prog. Histochem. Cytochem. 2013;48(3):103-140. doi: 10.1016/j. proghi.2013.09.001.
4. Gittes GK. Developmental biology of the pancreas: a comprehensive review. Dev Biol. 2009;326(1):4-35. doi: 10.1016/j. ydbio.2008.10.024.
5. Moldavskaja AA, Savishhev AV. Sovremennye vzgljady na formirovanie podzheludochnoj zhelezy v jembriogeneze [Modern views on the formation of the pancreas in embryogenesis]. Morfologija. 2008;133,(3):77-78. (Russian).
6. Goldman H, Wong I, Patel YC. A study of the structural and biochemical development of human fetal islets of Langerhans. Diabetes. 1982;31(10):897-902. https://doi.org/10.2337/diab.31.10.897.
7. Sessa F, Fiocca R, Tenti P, Solcia E, Tavani E, Pliteri S. Pancreatic polypeptide rich tissue in the annular pancreas. A distinctive feature of ventral primordium derivatives. Pathol. Anat. Histopathol. 1983;399(2):227-232.
8. Glushhenko IL. Morfometricheskaja harakteristika podzheludochnoj zhelezy cheloveka v jembriogeneze [Morphometric characteristics of the human pancreas in embryogenesis] [masters thesis]. Tjumen (Russia): Uralskaja gosudarstvennaja akademija Ministerstva zdravoohranenija; 2004. 24 p. (Russian).
9. Carlsson GL. Heller RS, Serup P, Hyttel P. Immunohistochemistry of pancreatic development in cattle and pig. Anat. Histol. Embryol. 2010;39(2):107-119. doi: 10.1111/j.1439-0264.2009.00985.x.
10. Heller RS, Stoffers DA, Liu A, Schedl A, Crenshaw EB, Madsen OD, Serup P. The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. Dev. Biol. 2004;268(1):123-134. doi: 10.1016/j.ydbio.2003.12.008.
11. Merkwitz C, Pessa-Morikawa T, Lochhead P, Reinhard G, Sakurai M, Iivanainen A, Ricken AM. The CD34 surface antigen is restricted to glucagon-expressing cells in the early developing bovine pancreas. Histochem. Cell Biol. 2011;135(1):59-71. doi: 10.1007/s00418-010-0775-x.
12. Oliver-Krasinski, JM, Staffers DA. On the origin of the β cell. Genes & Dev. 2008;22(15):1998-2021. Available from: http://www.genesdev.org/cgi/doi/10.1101/gad.1670808. (accessed 31.10.2017).
13. Denisov SD, Pivchenko TP. Dinamika strukturnyh izmenenij podzheludochnoj zhelezy v jembriogeneze beloj krysy [The dynamic of structural changes of the pancreas in embryogenesis of white rats]. In: Lobko PI, Pivchenko TP, editors. Sovremennye aspekty fundamentalnoj i prikladnoj morfologii: sbornik trudov nauchno-prakticheskoj konferencii. Minsk: BGMU; 2011. p. 102-106. (Russian).
14. Ku HT. Minireview: pancreatic progenitor cells – recent studies. Endocrinology. 2008;149(9):4312-4316. doi: 10.1210/ en.2008-0546.
15. Bobrik II, Davidenko LM. Differencirovka pankreaticheskih jendokrinocitov u cheloveka v jembriogeneze [Have a person of pancreatic endocrinocytes have a person in human embryogenesis]. Arhiv anatomii, gistologii i jembriologii. 1991;100(2):42-48. (Russian).
16. Meier JJ, Kцhler CU, Alkhatib B, Sergi C, Junker T, Klein HH, Schmidt WE, Fritsch H. Beta-cell development and turnover during prenatal life in humans. Eur. J. Endocrinol. 2010;162(3):559-568. doi: 10.1530/EJE-09-1053.
17. Jeon J, Correa-Medina M, Ricordi C, Edlund H, Diez JA. Endocrine cell clustering during human pancreas development. J. Histochem Cytochem. 2009;57(3):811-824. doi: 10.1369/jhc.2009.953307.
18. Riedel MJ, Asadi A, Wang R, Ao Z, Warnock GL, Kieffer TJ. Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas. Diabetologia. 2012;55(2):372-381. doi: 10.1007/s00125-011-2344-9.
19. Kaligin MS, Gumerova AA, Titova MA, Andreeva DI, Sharipova JeI, Kijasov AP. S-kit – marker stvolovyh kletok jendokrinocitov podzheludochnoj zhelezy cheloveka [C-kitis marker of human pancreatic endocrinocyte stem cells]. Morfologija. 2011;140(4):32-37. (Russian).
20. Herrera PL. Adult insulin - and glucagon- and glucagon-producing cells differentiate from two independent cell lineages. Development. 2000;127(1):2317-2322.
21. Bouwens L, Pipeleers DG. Extra-insular beta cells associated with ductules are frequent in adult human pancreas. Diabetologia. 1998;41(6):629-633. doi: 10.1007/s001250050960.
22. Redecker P, Seipelt A, Jцrns A, Bargsten G, Grube D. The microanatomy of canine islets of Langerhans: implications for intral-islet regulation. Anat. Embryol. 1992;185(2):131-141.
23. Polak M, Bouchareb-Banaei L, Scharfmann R, Czernichow P. Early pattern of differentiation in the human Pancreas. Diabetes. 2000;49(2):225-232.
24. Reddy S, Elliott RB. Ontogenic development of peptide hormones in the mammalian fetal pancreas. Experientia. 1988;44(1):1-9.
25. Miller K, Kim A, Kilimnik G, Jo J, Moka U, Periwal V, Hara M. Islet formation during the neonatal development in mice. PloS ONE. 2009;4(11):e7739.
26. Herbach N, Bergmayr M, Gцke B, Wolf E, Wanke R. Postnatal Development of Numbers and Mean Sizes of Pancreatic Islets and Beta-Cells in Healthy Mice and GIPRdn Transgenic Diabetic Mice. PLoS ONE. 2011;6(7): e22814.
27. Jo J, Kilimnik G, Kim A, Guo C, Periwal V, Hara M. Formation of pancreatic islets involves coordinated expansion of small islets and fission of large interconnected islet-like structures. Biophys. J. 2011;101(3):565-574. doi: 10.1016/j.bpj.2011.06.042.
28. Bouwens L. Islet morphogenesis and stem cell markers. Cell Biochem. Biophys. 2004;40(3Suppl.):81-88.
29. Kilimnik G, Kim A, Steiner DF, Friedman TC, Hara M. Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic α-cells in mouse models of β-cell regeneration. Islets. 2010;2(3):149-155.
30. Gorczyca J, Litwin JA, Pitynski K, Miodonski AJ. Vascular system of human fetal pancreas demonstrated by corrosion casting and scanning electron microscopy. Anat. Sci. Int. 2010;85(4):235-240. doi: 10.1007/s12565-010-0084-4.
31. Olsson R, Carlsson PO. A low-oxygenated subpopulation of pancreatic islets constitutes a functional reserve of endocrine cells. Diabetes. 2011;60(8):2068-2075. doi: 10.2337/db09-0877.
32. Murakami T, Hitomi S, Ohtsuka A, Taguchi T, Fujita T. Pancreatic insulo-acinar portal systems in humans, rats, and some other mammals: scanning electron microscopy of vascular casts. Microsc. Res. Tech. 1997;37(5-6):478-488. doi: 10.1002/(SICI)1097-0029(19970601)37:5/6<478::AIDJEMT10>3.0.CO;2-N.
33. Rodriguez-Diaz R, Abdulreda MH, Formoso AL, Gans I, Ricordi C, Berggren PO, Caicedo A. Innervation patterns of autonomic axons in the human endocrine pancreas. Cell Metab. 2011;14(1):45-54. doi: 10.1016/j.cmet.2011.05.008.
34. Putti, R, Maglio, M, Odierna, G. An immunocytochemical study of intrapancreatic ganglia, nerve fibres and neuroglandular junctions in Brockmann bodies of the tompot blenny (Blennius gattorugine), a marine teleost. J. Histochem. 2000;32:607-616.
35. Barker CJ, Leibiger IB, Berggren PO. The pancreatic islet as a signaling hub. Adv. Biol. Regul. 2013;53(1):156-163. doi: 10.1016/j.jbior.2012.09.011.
36. Kelly C, McClenaghan NH, Flatt PR. Role of islet structure and cellular interactions in the control of insulin secretion. Islets. 2011;3(2):41-47.
37. Rodriguez-Diaz R, Speier S, Molano RD, Formoso A, Gans I, Abdulreda MH, Cabrera O, Molina J, Fachado A, Ricordi C, Leibiger I, Pileggi A, Berggren PO, Caicedo A. Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function. Proc. Natl. Acad. Sci. U.S.A. 2012;109(52):21456-21461. doi: 10.1073/pnas.1211659110.
38. Aughsteen AA, Kataoka K. Morphometric studies on the juxta-insular and tele-insular acinar cells of the pancreas in normal and streptozotocin-induced diabetic rats. J. Electron microsc (Tokyo). 1993;42(2):79-87.
39. Honin GA, Gichev JuM, Semchenko VV. Provizornost jendokrinnoj chasti podzheludochnoj zhelezy u krupnogo rogatogo skota v jembriogeneze [The provisionality of endocrine part of cattles pancreas in embryogenesis]. Vestnik Omskogo GAU. 2016;22(2):153-157. (Russian).
40. Baltazar ET, Kitamura N, Hondo E, Narreto EC, Yamada J. Galanin-like immunoreactive endocrine cells in bovine pancreas. J. Anat. 2000;196(Pt. 2):285-291.
41. Tsui H, Paltser G, Chan Y, Dorfman R, Dosch HM. ‘Sensing’ the link between type 1 and type 2 diabetes. Diabetes Metab. Res. Rev. 2011;27(8):913-918. doi: 10.1002/dmrr.1279.
