METABOLIC DISORDERS OF AMINO ACIDS AND RELATED COMPOUNDS IN HEPATOBILIARY PATHOLOGY
Abstract
The review presents the data on the nature of the amino acid imbalance in various liver diseases and their complications. The pathogenetic mechanisms of the disorders of barrier, metabolic and excretory functions of the liver are considered, taking into account the influence of these processes on other organ systems.
References
1. Sorokina EJu. Ostrye narushenija funkcii pecheni u pacientov otdelenija intensivnoj terapii i metody metabolicheskoj terapii [Acute hepatic impairment in intensive care patients and metabolic methods]. Medicina neotlozhnyh sostojanij [Emergency Medicine]. 2015;(8):35-45. (Russian).
2. Indiveri C, Tonazzi A, Stipani I, Palmieri F. The purified and reconstituted ornithine/citrulline carrier from rat liver mitochondria catalyses a second transport mode: ornithine+/H+ exchange. Biochem. J. 1999;341(3):705-711.
3. Antonenko OM. Pechenochnaja jencefalopatija: osobennosti techenija i korrekcii metabolicheskih narushenij [Hepatic encephalopathy: features of the course and correction of metabolic disorders]. Hirurgija (Prilozhenie k zhurnalu Consilium Medicum) [Surgery. Consilium Medicum Magazine Supplement]. 2010;2:19-23. (Russian).
4. Shherbenkov IM. Pechenochnaja nedostatochnost [Liver failure]. Gastrojenterologija [Gastroenterology]. 2009;1:37-41. (Russian).
5. Serov VV, Aprosina ZG. Hronicheskie virusnye gepatity [Chronic viral hepatitis]. Moskva: Medicina; 2004. 583 p. (Russian).
6. Majer KP. Gepatit i posledstvija gepatita [Hepatitis and the effects of hepatitis]. Moskva: GJeOTAR-Media; 2004. 717 p. (Russian).
7. Bueverov AO, Maevskaja MV. Trudnye voprosy diagnostiki i lechenija pechenochnoj jencefalopatii [Difficult issues in the diagnosis and treatment of hepatic encephalopathy. Klinicheskie perspektivy gastrojenterologii, gepatologii [Clinical prospects of gastroenterology, hepatology]. 2005;10:9-15. (Russian).
8. Sitnikov IG, Maleev VV, Fedorov VN, Shoshin AA. Nejromediatornoe zveno patogeneza ostryh gepatitov V i S [The neurotransmitter link in the pathogenesis of acute hepatitis B and C]. Infekcionnye bolezni [Infectious diseases]. 2006;4(4):32-36. (Russian).
9. Shejko MI. K obmenu kateholaminov pri infekcionnom gepatite [To the exchange of catecholamines with infectious hepatitis] [masters thesis]. Minsk (Belarus): Belarusian State Institute for Advanced Medical Studies; 1975. 20 p. (Russian).
10. Shaposhnikov AM, Halchickij SE. Patohimija obmena fenilalanina, tirozina, triptofana i aktivnost fenilalaningndrokilazy pecheni pri virusnyh gepatitah [Pathochemistry of the metabolism of phenylalanine, tyrosine, tryptophan and the activity of liver phenylalanine indrocylase in viral hepatitis]. Estestvennye i tehnicheskie nauki [Natural and technical sciences]. 2007;2:137-154. (Russian).
11. Joy T, Walsh G, Tokmakejian S, Van Uum SH. Increase of urinary 5-hydroxyindoleacetic acid excretion but not serum chromogranin A following over-the-counter 5-hydroxytryptophan intake. Can. J. Gastroenterol. 2008;22(1):49-53. doi: 10.1155/2008/472159.
12. Glagovskij PB, Mamedov IS, Toguzov RT. Osnovnye metabolity adrenalina, noradrenalina, dofamina I serotonina v laboratornoj diagnostike narkomanij [The main metabolites of adrenaline, norepinephrine, dopamine and serotonin in the laboratory diagnosis of drug addiction]. Kliniko-laboratornyj konsilium [Clinical and laboratory consultation]. 2010;(1):27-34. (Russian).
13. Garaeva SN, Redkozubova GV, Postolati GV. Aminokisloty v zhivom organizme [Amino Acids in a Living Body]. Kishinev: ASM; 2009. 552 p. (Russian).
14. Zhang J, Song S, Pang Q, Zhang R, Zhou L, Liu S, Meng F, Wu Q, Liu C. Serotonin deficiency exacerbates acetaminophen-induced liver toxicity in mice. Sci. Rep. 2015;5:8098. doi: 10.1038/srep08098.
15. Alekseeva AS. Kliniko-morfologicheskie projavlenija hronicheskih gepatitov i cirrozov pecheni razlichnoj jetiologii vo vzaimosvjazi s psihologicheskim profilem I kachestvom zhizni pacientov [Clinical and morphological manifestations of chronic hepatitis and liver cirrhosis of various etiologies in relation to the psychological profile and quality of life of patients] [masters thesis]. Tomsk (Russia):Sibirskij gosudarstvennyj medicinskij universitet; 2010. 43 р. (Russian).
16. Alekceeva AS, Beloborodova JeI, Rachkovskij MI, Naumova EL, Lambrov EG, Filippova LP. Pokazateli obmena serotonina u bol'nyh s hronicheskimi gepatitami I cirrozami pecheni [Serotonin metabolism in patients with chronic hepatitis and cirrhosis]. Bjulleten jeksperimentalnoj biologii i mediciny [Bulletin of Experimental Biology and Medicine]. 2008;146(11):512-514. (Russian).
17. Mamedov IS, Glagovskij LB, Tjurin IA, Toguzov RT. Znachimost opredelenija osnovnyh metabolitov serotonina i kateholaminov (HVA, VMA, 5-HIAA) v klinicheskoj laboratornoj diagnostike [The importance of determining the major metabolites of serotonin and catecholamines (HVA, VMA, 5-HIAA) in clinical laboratory diagnostics]. Klinicheskaja laboratornaja diagnostika [Russian Clinical Laboratory Diagnostics]. 2007;9:80. (Russian).
18. Lelevich VV, Artemova OV. Sostojanie pula svobodnyh aminokislot krovi i pecheni pri hronicheskoj alkogolnoj intoksikacii [The state of the pool of free amino acids in the blood and liver in chronic alcohol intoxication]. Zhurnal Grodnenskogo gosudarstvennogo medicinskogo universiteta [Journal of the Grodno State Medical University]. 2010;(2):16-19. (Russian).
19. Fischer JE, Rosen HM, Ebeid AM, James JH, Keane JM, Soeters PB. The effect of normalization of plasma amino acids on hepatic encephalopathy in man. Surgery. 1976;80(1):77-91.
20. Fischer JE, Baldessarini RJ. False neurotransmitters and hepatic failure. Lancet. 1971;2(7715):75-80. doi: 10.1016/s0140-6736(71)92048-4.
21. Adamenko EI, Silivonchik NN, Popova OP, Poleshko GD, Kuvaeva ZI. Sostav svobodnyh aminokislot syvorotki krovi u bolnyh cirrozom pecheni [The composition of the free amino acids of blood serum in patients with cirrhosis of the liver]. Medicinskij zhurnal [Medical Journal]. 2005;1:16-19. (Russian).
22. Erjuhin IA, Shashkov BV. Jendotoksikoz v hirurgicheskoj praktike [Endotoxicosis in surgical practice]. Sankt-Peterburg: Logos; 1995. 304 p. (Russian).
23. Sheybak VM. Obmen svobodnyh aminokislot i KoA pri alkogolnoj intoksikacii [Exchange of free amino acids and CoA in alcohol intoxication]. Grodno: GrGMU; 1998. 153 p. (Russian).
24. Volf SB. Dinamika urovnja svobodnyh aminokislot pri razvitii gepatotoksicheskih reakcij na himioterapiju tuberkuleza [Dynamics of the level of free amino acids in the development of hepatotoxic reactions to tuberculosis chemotherapy]. Vestnik Vitebskogo gosudarstvennogo medicinskogo universiteta [Vestnik Of Vitebsk State Medical University]. 2007;6(4):76-82. (Russian).
25. Gulinskaya OV, Sheybak VM, Tsyirkunov VM. Ocenka pula svobodnyh aminokislot v syvorotke krovi pri kombinirovannom porazhenii pecheni u pacientov s saharnym diabetom 2-go tipa i hronicheskim gepatitom C [Evaluation of a pool of free amino acids in blood serum in combined liver damage in patients with type 2 diabetes mellitus and chronic hepatitis C]. Klinicheskaja infektologija i parazitologija [Clinical infectology and parasitology]. 2014;4:99-108. (Russian).
26. Jusupov AS, Daminova MN, Halikova ShA, Fajziev BO. Izmenenie aminokislotnogo sostava krovi pri hronicheskom virusnom gepatite C u detej [Change in blood amino acid composition in chronic viral hepatitis C in children]. Problemy i perspektivy sovremennoj nauki [Problems and prospects of modern science]. 2017;(17):68-71. (Russian).
27. Halikova ShA, Daminova MN. K voprosu o sostojanii aminokislotnogo spektra i oksida azota v syvorotke krovi pri hronicheskom virusnom gepatite С u detej [On the state of the amino acid spectrum and nitric oxide in blood serum in chronic viral hepatitis C in children]. Profilakticheskaja I klinicheskaja medicina [Preventive and clinical medicine]. 2010;(2):152-154. (Russian).
28. Pozdeev VK, Pozdeev NV, Nikitina OE. Gipergomocisteinemija, gipercisteinemija, glutamatnaja jeksajtotoksichnost, deficit taurina pri gepatite C [Hyperhomocysteinemia, hypercysteinemia, glutamate excitotoxicity, taurine deficiency in hepatitis C]. Rossijskij zhurnal gastrojenterologii, gepatologii, koloproktologii [Russian Journal of Gastroenterology, Hepatology, Coloproctology]. 2015;25(3):49-60. (Russian).
29. Pavlov VA. Vlijanie mikobakterij na adaptivnuju perestrojku v organizme morskih svinok pri dlitelnom vozdejstvii na nih PAU-soderzhashhih veshhestv [The effect of mycobacteria on adaptive rearrangement in the body of guinea pigs with prolonged exposure to PAH-containing substances]. Problemy tuberkuleza [Tuberculosis problems]. 1998;(1):51-53. (Russian).
30. Pozdeev VK. Rol nejromoduljatorov - glicina, D-serina I taurina v formirovanii jepileptiformnogo sindroma [The role of neuromodulators - glycine, D-serine and taurine in the formation of epileptiform syndrome]. Rossijsskij nejrohirurgicheskij zhurnal im. professora A.L. Polenova [Russian neurosurgical journal named after professor A. L. Polenov]. 2014;6:366-370. (Russian).
31. Shih EV, Mahova AA, Shumjanceva VV. Vozmozhnosti ispolzovanija taurina v kachestve sredstva, preduprezhdajushhego lekarstvennoe porazhenie pecheni [Possibilities of using taurine as a means of preventing drug damage to the liver]. Russkij medicinskij zhurnal [Russian Medical Journal]. 2015;23(13):754-758. (Russian).
32. Abdikerimov MM, Zholdoshev ST. Sravnitelnaja harakteristika gormonalnogo statusa u bolnyh HGS [Comparative characteristics of hormonal status in patients with CHC]. Mezhdunarodnyj zhurnal prikladnyh i fundamentalnyh issledovanij [International Journal of Applied and Basic Research]. 2016;(1):29-31. (Russian).
33. Kopin IJ, Jimerson DC, Markey SP, Ebert MH, Polinsky RJ. Disposition and metabolism of MHPG in humans: application to studies in depression. Pharmacopsychiatry. 1984;17(1):3-8. doi: 10.1055/s-2007-1017399.
1.png)
