LIVER SARCOIDOSIS
Abstract
Background. Despite the fact that sarcoidosis is a rare liver pathology carrying out the differential diagnosis between it and other focal liver lesions causes difficulties.
Objective – to present the morphological signs and features of liver damage in sarcoidosis.
Materials and methods. The object of the study were liver fragments of a patient died due to generalized sarcoidosis. The pieces of the liver intended for light microscopy were fixed in 10% formalin solution and embedded in paraffin after posting. Histological sections were stained with hematoxylin and eosin, as well as pikrofuksin by van Gieson.
Results. The morphological stages of granuloma formation are represented: the accumulation of monocytes and macrophages in the lesion; the formation of macrophage granulomas; eosinophilic masses resembling fibrinoid necrosis are detected in the central zones of granulomas; the formation of epithelioid cell granulomas (giant multinucleated cells); fibrosis with the appearance of argyrophil and collagen fibers, the development of hyalinosis; fibrinoid swelling of connective tissue fibers with necrobiosis without loss of fibrin and without the formation of caseous necrosis. Various localization of granulomas (inside the lobules, in portal tracts), fusion of granulomas with the formation of foci of various sizes visible to the naked eye are shown.
Conclusion. Clinical and laboratory diagnostic methods, including instrumental imaging methods, do not accurately identify liver sarcoidosis. Morphological diagnosis of focal liver lesions is the most accurate method for early detection of liver sarcoidosis.
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