DYNAMICS OF CYTOKINE STATUS IN PATIENTS WITH OPIOID DEPENDENCE COMBINED WITH CHRONIC HEPATITIS C
Abstract
Background. A wide prevalence of chronic viral hepatitis, HIV infection, and other secondary immunodeficiency states in drug dependent patients necessitates the evaluation of the serum cytokine profile, which is a reliable factor in assessing the severity of the course and prognosis of opioid dependence (OD).
Objective. The aim of the research was to assess the pathogenetic role of the correlation between the TNF-alpha and interleukin-4 (IL-4) concentration in serum of patients with OD and the presence or absence of comorbid chronic hepatitis C.
Materials and methods We observed 138 patients with opioid dependence (83 men and 55 women) aged from 19 to 48 years, including 89 patients with associated chronic hepatitis C (67 men and 22 women) aged from 21 to 48 years. The serum levels of TNF-alfa and IL-4 and their correlations were determined in all patients.
Results. Low activity of CHC in patients with OD was accompanied by insignificant shift in cytokine balance toward the increase of systemic inflammation during early (0.77±0.04) and late (0.71±0.06) abstinent periods. Patients with moderate activity of CHC showed a considerable shift of cytokine balance toward the increase of systemic inflammation with the rise of the TNF - alfa/IL - 4 coefficient to 1.57±0.07 during the period of acute intoxication and gradual increase of this index during early (1.80±0.09) and late (1.63±0.07) abstinent periods as well as during the period of remission (2.09±0.08).
Conclusion. Activity of CHC influences the nature of the shift in the balance of cytokines.
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