HELICOBACTER PYLORI PLAYS A ROLE IN THE ETIOLOGY OF CHRONIC GASTRITIS AND CHRONIC DUODENITIS: IS IT THE FINAL STATEMENT?
Abstract
Background. The representatives of the herpes family of viruses occupy one of the leading places in the etiology of infectious diseases in adults and children.
Objective. To reveal the frequency of occurrence of type 1 and 2 herpes simplex viruses (HSV), Epstein-Barr virus (VEB), human papillomavirus (HPV), cytomegalovirus (CMV) and Helicobacter pylori (H. pylori) in the stomach and duodenum (DD) mucous membrane (MM) in patients with chronic gastritis (CG) and chronic duodenitis (CD), as well as to assess the effect of detected infections on the morphological and immunological changes of mucous membrane.
Material and methods. 116 patients (66 children and 50 adults) with verified CG and CD were examined. The patients underwent esophagogastroduodenoscopy (EGDS) with biopsy of the MM of the stomach and duodenal bulb.
The main morphological parameters were evaluated according to the criteria of the modified Sydney system. The antigens of HSV-1, HSV-2, VEB, CMV and HPV were detected in the paraffin sections of bioptates by the streptavidin -biotin method. The expression of CD45 +, CD3 +, CD4 +, CD8 +, CD20 + was assessed by immunohistochemical typing with the help of monoclonal antibodies in the stomach and duodenal MM.
Results. The relationship between morphological and immunological parameters and the nature of infection of the stomach and duodenal MM in children and adults was established.
Conclusion. The viral antigens were found in the stomach and duodenal MM in 57% and 64% of the examined children and adults respectively. HSV-1 affects the severity and activity of chronic inflammation of the stomach MM in children and adults. The indices that characterize the state of local immunity of the MM in patients with CG and CD were significantly associated with the expression of the antigens of the studied viruses, but not with the presence of Н. руlori.
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