MORPHOFUNCTIONAL INDICES OF THE STOMACH OF THE SECOND GENERATION OFFSPRING OF WHITE RATS, OBTAINED FROM FEMALE RATS, BORN FROM MOTHERS WITH CHOLESTASIS
Abstract
Background. Maternal cholestasis delays the development of sex glands in the offspring, which leads to a decrease in its fertilizing ability. Whether this affects the development of organs in the second-generation offspring obtained from them is unknown.
Objective. To study the features of the formation of structural and cytochemical properties of the stomach in the second-generation offspring, obtained from female rats, which were born from mothers with cholestasis.
Materiasl and methods. The researches were carried out on 48 pups aged 2, 15, 45 and 90 days, born from females, who developed under maternal cholestasis. The methods of the study were histological, histochemical and statistical ones.
Results. It has been established that the delay in the development of membranes of the stomach and its proper glands, disturbances in the structural and functional properties of the exocrinocytes occur in the offspring of the second generation, born from female rats, which developed under the conditions of maternal cholestasis. These changes are especially pronounced early after birth.
Conclusion. Cholestasis of pregnancy has a negative effect on the development of the stomach, not only in the offspring of the first generation, but also in the second-generation offspring obtained from them.
References
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