HUMAN PARECHOVIRUS INFECTION IN PATIENTS WITH INFECTIOUS PATHOLOGY OF THE GASTROINTESTINAL TRACT AND MOLECULAR GENETIC CHARACTERISTIC OF CAUSATIVE AGENTS
Abstract
Background. Human parechoviruses (HPeVs) are widely distributed RNA viruses that are found in patients with infectious diseases of the digestive system. HPeV infection has not been diagnosed in the Republic of Belarus until now therefore information about its epidemiology was unavailable.
Objective is to study the results of detection and molecular typing of HPeV from patients with infectious pathology of the gastrointestinal tract.
Materials and methods. Clinical material from 276 patients with signs of gastroenteritis, collected in 2016–2018 years, was studied. Detection of HPeV was performed by RT-qPCR, while genotyping - by sequencing the VP1 gene.
Results. HPeV infection was detected in 4.7% of the examined patients. Sequence analyses showed that all HPeV isolates belonged to type 1.
Conclusion. HPeV makes a contribution to the etiological structure of intestinal viral infections registered in the Republic of Belarus. The population of HPeV-1 identified from the patients with gastroenteritis was characterized by considerable heterogeneity.
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