МЕХАНИЗМЫ ВОЗДЕЙСТВИЯ ЖЕЛЧНЫХ КИСЛОТ НА ПРОТОКОВЫЕ КЛЕТКИ ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ
Аннотация
Цель обзора – представить анализ современных литературных сведений о механизмах влияния желчных кислот, попадающих в панкреатические протоки, на дуктальные клетки. Показано, что воздействие желчных кислот специфично и зависит от их концентрации. Как свидетельствуют результаты экспериментов in vitro и in vivo, низкие концентрации желчных кислот с помощью внутриклеточных механизмов усиливают дуктальную секрецию НСО3- и жидкости. Увеличенный объём жидкости может способствовать уменьшению концентрации желчных кислот, вымыванию из панкреатических протоков и предотвращению их воздействия на ацинарные клетки. Высокие концентрации желчных кислот приводят к нарушению целостности эпителиального дуктального барьера. В дуктулоцитах наблюдается устойчивый патологический подъём цитозольного Са2+, повреждение митохондрий, истощение АТФ, блок базолатерального и люминального транспортного механизма ионов. Предполагается, что в этих условиях желчные кислоты могут достигать и повреждать ацинарные клетки, способствуя развитию острого билиарного панкреатита.
Литература
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