RETINOL AND RETINOL-BINDING PROTEIN CORRELATION WITH NON-INVASIVE FIBROSIS MARKERS (PDGF-BB, GF-Β1) IN CHRONIC LIVER DISEASES
Abstract
Background. Perisinusoidal lipocytes (HSC) and retinol (R) metabolism play an important role in liver fibrosis.
Objective. To estimate R and retinol-binding protein type 4 (RBP4) correlation with non-invasive fibrosis markers in patients with chronic liver diseases.
Material and methods. The subjects of the study were 129 adult patients with chronic diffuse liver diseases, who were divided into 2 groups: those with chronic hepatitis - 104 patients, and those with liver cirrhosis - 25 patients. In addition, 48 patients were further subdivided according to liver fibrosis stages. Blood levels of R, RBP4, platelet growth
factor BB, and transforming growth factor β1 (TGF-β1) were determined in the patients.
Results. Differences in R and RBP4 content were established in the patients with different stages of liver fibrosis, the most informative values and coefficients for liver fibrosis staging were found. High blood levels of retinol and TGF-β1 are indicative of transformation of HSC into myofibroblasts, increased synthesis of profibrogenic factors, including TGF-β1,
and the progression of liver fibrosis.
Conclusions. Laboratory monitoring of R, RBP4 and TGF-β1 levels as well as of RBP4/R and PDGF-BB/R coefficients is an additional test for the diagnosis of liver fibrosis in chronic liver diseases.
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