MORPHOLOGICAL CHANGES IN RAT LIVER IN HYPERHOMOCYSTEINEMIA
Abstract
Background. Hyperhomocysteinemia is a pathogenetic factor of a number of diseases. The liver is a key organ in homocysteine metabolism.Objective – to study the structure of rat liver in hyperhomocysteinemia.
Materials and methods. Hyperhomocysteinemia was induced by methionine load. The liver underwent a morphological study.
Results. Hyperhomocysteinemia produces local structural changes in the microvascular liver blood flow, stimulating fibrogenesis. The majority of hepatocytes are characterized by morphological signs indicating an activation of biosynthetic processes and energy production in cells. In some hepatocytes dystrophic changes are noted, affecting mainly the nuclear apparatus and mitochondria. Specific structural changes in the mitochondria and hepatocyte endoplasmic reticulum are registered.
Conclusion. The specific changes in the liver structure were registered in methionine load-induced hyperhomocysteinemia.
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